First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 11/20/2024

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Exelixis, Inc. EXEL 30161Q104 Health Care 1,500,329 $51,986,399.85 4.59%
Natera, Inc. NTRA 632307104 Health Care 302,579 $50,796,962.52 4.49%
Corcept Therapeutics Incorporated CORT 218352102 Health Care 866,247 $48,587,794.23 4.29%
Intra-Cellular Therapies, Inc. ITCI 46116X101 Health Care 519,450 $44,485,698.00 3.93%
argenx SE (ADR) ARGX 04016X101 Health Care 73,326 $43,395,793.32 3.83%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,637,642 $42,914,435.34 3.79%
Incyte Corporation INCY 45337C102 Health Care 595,186 $42,287,965.30 3.74%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 340,754 $42,011,560.66 3.71%
Catalyst Pharmaceuticals, Inc. CPRX 14888U101 Health Care 1,948,200 $41,204,430.00 3.64%
Gilead Sciences, Inc. GILD 375558103 Health Care 463,258 $41,058,556.54 3.63%
United Therapeutics Corporation UTHR 91307C102 Health Care 109,858 $40,024,565.14 3.54%
Repligen Corporation RGEN 759916109 Health Care 283,487 $39,376,344.30 3.48%
Waters Corporation WAT 941848103 Health Care 109,937 $39,332,160.49 3.47%
Alkermes Plc ALKS G01767105 Health Care 1,361,246 $37,992,375.86 3.36%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 81,697 $36,864,137.31 3.26%
Illumina, Inc. ILMN 452327109 Health Care 270,396 $35,605,745.28 3.14%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 559,398 $34,995,938.88 3.09%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 316,068 $35,039,298.48 3.09%
Amgen Inc. AMGN 031162100 Health Care 119,852 $34,501,795.24 3.05%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 138,414 $34,436,019.06 3.04%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,672,487 $34,202,359.15 3.02%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 742,521 $33,977,760.96 3.00%
BioNTech SE (ADR) BNTX 09075V102 Health Care 326,533 $33,352,080.62 2.95%
Biogen Inc. BIIB 09062X103 Health Care 208,905 $32,589,180.00 2.88%
Bruker Corporation BRKR 116794108 Health Care 609,755 $32,542,624.35 2.87%
BeiGene, Ltd. (ADR) BGNE 07725L102 Health Care 166,681 $32,379,451.06 2.86%
Mettler-Toledo International Inc. MTD 592688105 Health Care 27,123 $31,649,828.70 2.80%
Exact Sciences Corporation EXAS 30063P105 Health Care 554,589 $29,226,840.30 2.58%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 38,746 $28,801,839.10 2.54%
Moderna, Inc. MRNA 60770K107 Health Care 675,135 $24,939,486.90 2.20%
US Dollar $USD Other 1,626,102 $1,626,101.60 0.14%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.