First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 6/28/2024

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 237,106 $57,616,758.00 5.20%
Corcept Therapeutics Incorporated CORT 218352102 Health Care 1,497,686 $48,659,818.14 4.39%
United Therapeutics Corporation UTHR 91307C102 Health Care 151,387 $48,224,328.85 4.35%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 911,958 $47,750,120.88 4.31%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 88,789 $41,617,180.08 3.75%
Amgen Inc. AMGN 031162100 Health Care 131,736 $41,160,913.20 3.71%
Biogen Inc. BIIB 09062X103 Health Care 177,669 $41,187,227.58 3.71%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 38,922 $40,908,189.66 3.69%
Natera, Inc. NTRA 632307104 Health Care 372,721 $40,361,957.09 3.64%
argenx SE (ADR) ARGX 04016X101 Health Care 93,144 $40,055,645.76 3.61%
Moderna, Inc. MRNA 60770K107 Health Care 334,890 $39,768,187.50 3.59%
Incyte Corporation INCY 45337C102 Health Care 653,864 $39,637,235.68 3.57%
Mettler-Toledo International Inc. MTD 592688105 Health Care 27,920 $39,020,712.80 3.52%
Intra-Cellular Therapies, Inc. ITCI 46116X101 Health Care 534,463 $36,605,370.87 3.30%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 261,477 $35,997,538.59 3.25%
Catalyst Pharmaceuticals, Inc. CPRX 14888U101 Health Care 2,313,444 $35,835,247.56 3.23%
BeiGene, Ltd. (ADR) BGNE 07725L102 Health Care 249,192 $35,552,222.64 3.21%
Gilead Sciences, Inc. GILD 375558103 Health Care 517,273 $35,490,100.53 3.20%
Alkermes Plc ALKS G01767105 Health Care 1,441,879 $34,749,283.90 3.13%
Exelixis, Inc. EXEL 30161Q104 Health Care 1,543,649 $34,685,793.03 3.13%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,054,298 $33,382,342.50 3.01%
BioNTech SE (ADR) BNTX 09075V102 Health Care 407,158 $32,719,216.88 2.95%
Beam Therapeutics Inc. BEAM 07373V105 Health Care 1,357,912 $31,815,878.16 2.87%
Waters Corporation WAT 941848103 Health Care 109,125 $31,659,345.00 2.85%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 381,815 $31,434,828.95 2.83%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,203,370 $30,240,688.10 2.73%
Illumina, Inc. ILMN 452327109 Health Care 284,247 $29,669,701.86 2.68%
Repligen Corporation RGEN 759916109 Health Care 205,272 $25,876,588.32 2.33%
Bruker Corporation BRKR 116794108 Health Care 402,040 $25,654,172.40 2.31%
Exact Sciences Corporation EXAS 30063P105 Health Care 493,560 $20,852,910.00 1.88%
US Dollar $USD Other 726,269 $726,268.81 0.07%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.