First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 3/28/2025

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
BeiGene, Ltd. (ADR) ONC 07725L102 Health Care 211,984 $56,682,401.76 5.25%
Intra-Cellular Therapies, Inc. ITCI 46116X101 Health Care 394,852 $52,045,442.12 4.82%
Gilead Sciences, Inc. GILD 375558103 Health Care 416,775 $46,591,277.25 4.31%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 709,460 $45,291,926.40 4.19%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 91,464 $45,063,398.16 4.17%
Alkermes Plc ALKS G01767105 Health Care 1,334,032 $44,303,202.72 4.10%
Amgen Inc. AMGN 031162100 Health Care 142,852 $43,848,421.40 4.06%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 157,405 $42,256,946.30 3.91%
Corcept Therapeutics Inc. CORT 218352102 Health Care 751,447 $41,051,549.61 3.80%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 555,944 $39,716,639.36 3.68%
Exelixis, Inc. EXEL 30161Q104 Health Care 1,039,964 $38,166,678.80 3.53%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,170,312 $37,047,225.84 3.43%
Mettler-Toledo International Inc. MTD 592688105 Health Care 30,934 $36,412,102.06 3.37%
Waters Corporation WAT 941848103 Health Care 98,486 $35,667,689.76 3.30%
Biogen Inc. BIIB 09062X103 Health Care 251,712 $34,829,389.44 3.22%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 53,755 $34,261,286.80 3.17%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,691,176 $33,654,402.40 3.12%
argenx SE (ADR) ARGX 04016X101 Health Care 57,079 $33,628,092.85 3.11%
Repligen Corporation RGEN 759916109 Health Care 241,892 $32,270,811.72 2.99%
Incyte Corporation INCY 45337C102 Health Care 531,039 $32,180,963.40 2.98%
United Therapeutics Corporation UTHR 91307C102 Health Care 102,639 $31,507,093.83 2.92%
Natera, Inc. NTRA 632307104 Health Care 214,055 $30,811,076.70 2.85%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 265,861 $30,084,830.76 2.79%
BioNTech SE (ADR) BNTX 09075V102 Health Care 304,920 $28,952,154.00 2.68%
Exact Sciences Corporation EXAS 30063P105 Health Care 663,001 $28,946,623.66 2.68%
Moderna, Inc. MRNA 60770K107 Health Care 886,617 $27,591,521.04 2.55%
Veracyte, Inc. VCYT 92337F107 Health Care 901,770 $27,161,312.40 2.51%
Bruker Corporation BRKR 116794108 Health Care 616,313 $25,934,451.04 2.40%
Illumina, Inc. ILMN 452327109 Health Care 274,047 $21,923,760.00 2.03%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 300,183 $21,135,885.03 1.96%
US Dollar $USD Other 1,221,433 $1,221,432.71 0.11%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.