First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 3/28/2025

Total Number of Holdings (excluding cash): 76

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Intra-Cellular Therapies, Inc. ITCI 46116X101 Pharmaceuticals and Biotechnology 205,992 $27,151,805.52 2.83%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 843,023 $26,445,631.51 2.75%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 181,834 $24,809,430.96 2.58%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 645,811 $23,701,263.70 2.47%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 402,801 $23,567,886.51 2.45%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 170,368 $22,682,795.52 2.36%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 119,862 $22,315,907.16 2.32%
Jazz Pharmaceuticals Plc JAZZ G50871105 Pharmaceuticals and Biotechnology 174,629 $21,465,396.68 2.23%
Centene Corporation CNC 15135B101 Health Care Providers 354,994 $21,313,839.76 2.22%
Elevance Health Inc. ELV 036752103 Health Care Providers 46,637 $20,147,184.00 2.10%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 135,853 $19,554,680.82 2.04%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 140,633 $19,459,388.21 2.03%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 72,446 $19,383,651.76 2.02%
Premier, Inc. (Class A) PINC 74051N102 Health Care Providers 1,014,411 $19,415,826.54 2.02%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 59,112 $19,084,309.20 1.99%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 114,042 $19,082,647.86 1.99%
Roivant Sciences Ltd. ROIV G76279101 Pharmaceuticals and Biotechnology 1,817,880 $18,869,594.40 1.96%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 60,950 $18,709,821.50 1.95%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 1,775,848 $18,486,577.68 1.92%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 162,874 $18,284,235.24 1.90%
DaVita Inc. DVA 23918K108 Health Care Providers 115,041 $17,281,459.02 1.80%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 65,900 $17,051,625.00 1.77%
Masimo Corporation MASI 574795100 Medical Equipment and Services 104,080 $17,022,284.00 1.77%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 1,153,111 $16,731,640.61 1.74%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 542,384 $16,336,606.08 1.70%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 32,961 $16,211,538.24 1.69%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 24,152 $15,393,518.72 1.60%
The Cigna Group CI 125523100 Health Care Providers 46,727 $15,188,144.08 1.58%
Chemed Corporation CHE 16359R103 Health Care Providers 24,355 $14,751,823.50 1.54%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 42,990 $14,709,458.40 1.53%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 238,652 $14,634,140.64 1.52%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 89,222 $14,606,533.62 1.52%
Charles River Laboratories International, Inc. CRL 159864107 Pharmaceuticals and Biotechnology 93,199 $14,497,104.45 1.51%
Veeva Systems Inc. (Class A) VEEV 922475108 Health Care Providers 61,371 $14,373,701.91 1.50%
Encompass Health Corporation EHC 29261A100 Health Care Providers 139,722 $14,081,183.16 1.47%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 161,534 $14,155,224.42 1.47%
Humana Inc. HUM 444859102 Health Care Providers 50,858 $13,456,009.64 1.40%
Stryker Corporation SYK 863667101 Medical Equipment and Services 35,838 $13,062,951.00 1.36%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 186,464 $12,795,159.68 1.33%
ResMed Inc. RMD 761152107 Medical Equipment and Services 56,423 $12,409,674.62 1.29%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 486,367 $12,261,312.07 1.28%
Viatris Inc. VTRS 92556V106 Pharmaceuticals and Biotechnology 1,381,881 $11,994,727.08 1.25%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 186,815 $11,320,989.00 1.18%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 94,530 $10,697,014.80 1.11%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 76,052 $9,949,122.64 1.04%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 72,499 $9,990,362.20 1.04%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 334,586 $9,388,483.16 0.98%
GE HealthCare Technologies Inc. GEHC 36266G107 Medical Equipment and Services 110,031 $8,803,580.31 0.92%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 17,005 $8,775,260.20 0.91%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 37,917 $8,626,117.50 0.90%
Labcorp Holdings Inc. LH 504922105 Medical Equipment and Services 37,512 $8,628,510.24 0.90%
Waters Corporation WAT 941848103 Medical Equipment and Services 23,188 $8,397,766.08 0.87%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 116,199 $8,239,671.09 0.86%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 16,535 $8,270,145.60 0.86%
Revvity, Inc. RVTY 714046109 Medical Equipment and Services 77,074 $8,140,555.88 0.85%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 43,775 $7,765,247.25 0.81%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 64,033 $7,472,010.77 0.78%
Enovis Corporation ENOV 194014502 Medical Equipment and Services 196,039 $7,402,432.64 0.77%
Inspire Medical Systems, Inc. INSP 457730109 Medical Equipment and Services 46,403 $7,296,407.72 0.76%
Sarepta Therapeutics, Inc. SRPT 803607100 Pharmaceuticals and Biotechnology 70,748 $4,981,366.68 0.52%
Baxter International Inc. BAX 071813109 Medical Equipment and Services 138,282 $4,667,017.50 0.49%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 17,136 $4,600,330.56 0.48%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Pharmaceuticals and Biotechnology 61,346 $4,382,558.24 0.46%
Steris Plc STE G8473T100 Medical Equipment and Services 19,616 $4,374,368.00 0.46%
Eli Lilly and Company LLY 532457108 Pharmaceuticals and Biotechnology 5,223 $4,295,969.73 0.45%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 24,748 $4,036,646.28 0.42%
Medpace Holdings, Inc. MEDP 58506Q109 Pharmaceuticals and Biotechnology 12,137 $3,791,113.32 0.39%
Danaher Corporation DHR 235851102 Medical Equipment and Services 17,566 $3,615,961.10 0.38%
The Cooper Companies, Inc. COO 216648501 Medical Equipment and Services 43,863 $3,674,403.51 0.38%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 51,849 $3,512,251.26 0.37%
Exact Sciences Corporation EXAS 30063P105 Pharmaceuticals and Biotechnology 71,762 $3,133,128.92 0.33%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 19,339 $3,078,962.19 0.32%
Apellis Pharmaceuticals, Inc. APLS 03753U106 Pharmaceuticals and Biotechnology 126,364 $3,066,854.28 0.32%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 191,375 $3,096,447.50 0.32%
Bruker Corporation BRKR 116794108 Medical Equipment and Services 68,787 $2,894,556.96 0.30%
West Pharmaceutical Services, Inc. WST 955306105 Medical Equipment and Services 12,310 $2,735,282.00 0.28%
US Dollar $USD Other 793,438 $793,438.33 0.08%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.