Innovative Health Care Portfolio, Series 21

Innovation is important to the success of any business, but may be most profound in the health care sector with the potential to improve the quality of life and life expectancy of millions. Innovation in the health care sector is accelerating. Advances include cutting edge gene and cell therapies, the use of artificial intelligence (AI), machine learning tools, the application of database systems, and other innovations from outside the industry. We believe transformative shifts within the health care sector are creating opportunities for companies that embrace innovation in today’s new era of technological and medical advances.

As researchers and companies work to apply the latest advances in lifesaving medical drugs and devices, the government has been working to streamline its drug and device approval process. Statistics show a need for more efficiency in the health care system to prioritize early diagnoses and prevention of diseases. The health care industry is undergoing fundamental transformations as a shift toward an aging population, prevalence of chronic diseases and advances in innovative technologies continue to increase health care demand and expenditures. According to Centers for Medicare & Medicaid Services (CMS), from 2022-2031 it is projected that health care spending will grow at an average rate of 5.4% annually.

Access To Transforming Themes

The Innovative Health Care Portfolio provides access to health care companies that are involved in areas that we believe are driving innovation:

Robotic Surgery | Surgical robots are relied upon to assist human surgeons, aiding in procedures that require great precision. The global market for surgical robots is expected to experience a compound annual growth rate (CAGR) of 9.5% from 2024-2030, according to Grand View Research.

Rare Disease | According to the World Economic Forum, approximately 7,000 rare diseases have been identified and affect approximately 475 million people worldwide, but the vast majority of them have no specific treatment.

Gene and Cell Therapy | This type of therapy seeks to modify genetic material to improve functioning or fight disease. Currently, there are more than 4,000 cell, gene, and RNA therapies in development to target a broad range of diseases.¹

Electronic Health Care | The global electronic health records (EHR) market size was estimated at $29.1 billion in 2023 and is anticipated to grow at a CAGR of 4.1% from 2024 to 2030.² EHR solutions may play a key role in providing value based personalized health care and seek to provide the best outcome for patients by providing more effective clinical workflow, support for clinical decision making, patient safety, and ensuring fewer medical errors.

Infectious Disease | Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread, directly or indirectly, from one person to another. Worldwide, one of the leading infectious diseases is tuberculosis (TB) which is estimated to have caused approximately 1.3 million deaths in 2022.³ Investment in infectious disease has the potential to prevent needless deaths, dramatically reduce health care costs and improve the quality of life for millions.

Oncology | The global oncology/cancer drugs market was valued at $201.8 billion in 2023 and is estimated to rise to $518.3 billion by 2032, growing at a CAGR of 11.3% from 2024 to 2032.⁴

Advanced Life Sciences | The combination of technology and health care, or life science, is a broad and growing sector of the economy. According to a report from Cushman & Wakefield, rapid technological advances and surging demand from an aging population are creating a positive environment for life sciences growth.

¹  American Society of Gene + Cell Therapy and Citeline
²  Grand View Research
³  World Health Organization
⁴  Fortune Business Insights

Portfolio Objective

This unit investment trust seeks above-average capital appreciation; however, there is no assurance the objective will be met.

You should consider the portfolio's investment objectives, risks, and charges and expenses carefully before investing. Contact your financial professional or call First Trust Portfolios L.P. at 1.800.621.1675 to request a prospectus, which contains this and other information about the portfolio. Read it carefully before you invest.

Risk Considerations
An investment in this unmanaged unit investment trust should be made with an understanding of the risks involved with owning common stocks, such as an economic recession and the possible deterioration of either the financial condition of the issuers of the equity securities or the general condition of the stock market.

You should be aware that the portfolio is concentrated in stocks in the health care sector which involves additional risks, including limited diversification. The companies engaged in the health care sector are subject to fierce competition, high research and development costs, governmental regulations, loss of patent protection, and changing consumer spending trends. In addition, health crises, such as a pandemic outbreak, can severely impact the health care industry in particular.

Securities of non-U.S. issuers are subject to additional risks, including currency fluctuations, political risks, withholding, the lack of adequate financial information, and exchange control restrictions impacting non-U.S. issuers.

An investment in a portfolio containing small-cap and mid-cap companies is subject to additional risks, as the share prices of small-cap companies and certain mid-cap companies are often more volatile than those of larger companies due to several factors, including limited trading volumes, products, financial resources, management inexperience and less publicly available information.

Large capitalization companies may grow at a slower rate than the overall market.

As the use of Internet technology has become more prevalent in the course of business, the trust has become more susceptible to potential operational risks through breaches in cybersecurity.

Ongoing armed conflicts between Russia and Ukraine in Europe and among Israel, Hamas and other militant groups in the Middle East, have caused and could continue to cause significant market disruptions and volatility within the markets in Russia, Europe, the Middle East and the United States. The hostilities and sanctions resulting from those hostilities could have a significant impact on certain investments as well as performance.

The ongoing effects of the COVID-19 global pandemic, or the potential impacts of any future public health crisis, may cause significant volatility and uncertainty in global financial markets. While vaccines have been developed, there is no guarantee that vaccines will be effective against future variants of the disease.

The value of the securities held by the trust may be subject to steep declines or increased volatility due to changes in performance or perception of the issuers.

This UIT is a buy and hold strategy and investors should consider their ability to hold the trust until maturity. There may be tax consequences unless units are purchased in an IRA or other qualified plan.